A partition coefficient is the ratio of the concentration of a substance in one medium or phase (C1) to the concentration in a second phase (C2) when the two concentrations are at equilibrium; that is, partition coefficient = (C1/C2)equil.
Is a high partition coefficient better?
unit of measure called the partition coefficient. The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.
What are the factors affecting distribution coefficient?
Factors affecting Distribution Coefficient- The value of K depends upon the temperature , nature of solute , nature of two solvents . It does not depend upon the amount of solute or solvents taken.
What does the partition coefficient tell you?
a. Partition Coefficient. The partition coefficient is the measure of the lipophilicity of a drug and an indication of its ability to cross the cell membrane. It is defined as the ratio between un-ionized drug distributed between the organic and aqueous layers at equilibrium.
What does LogD measure?
LogD is a distribution coefficient widely used to measure the lipophilicity of ionizable compounds, where the partition is a function of the pH. For non- ionizable compounds LogP = LogD throughout pH range, whereas for ionizable compounds LogD takes into account the partition of both ionized and non-ionized forms.
Is lipophilic the same as hydrophobic?
Hydrophobic is often used interchangeably with lipophilic, “fat-loving”. However, the two terms are not synonymous. While hydrophobic substances are usually lipophilic, there are exceptions, such as the silicones and fluorocarbons.
How is Lipophilicity measured?
The lipophilicity of a compound is most commonly quantified by measuring the extent of distribution between an aqueous phase and a hydrophobic phase such as 1-octanol.
What is Clogp of a drug?
Druglikeness is a qualitative concept used in drug design for how “druglike” a substance is with respect to factors like bioavailability. It is estimated from the molecular structure before the substance is even synthesized and tested.
What makes a compound lipophilic?
Definition: Lipophilic or ‘lipid-loving’ molecules are attracted to lipids. A substance is lipophilic if it is able to dissolve much more easily in lipid (a class of oily organic compounds) than in water.