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What happens when alpha 2 receptors are stimulated?

Alpha 2 receptors in the brain stem and in the periphery inhibit sympathetic activity and thus lower blood pressure. Alpha 2 receptor agonists such as clonidine or guanabenz reduce central and peripheral sympathetic overflow and via peripheral presynaptic receptors may reduce peripheral neurotransmitter release.

What happens when beta-1 receptors are stimulated?

Beta-1 receptors are located in the heart. When beta-1 receptors are stimulated they increase the heart rate and increase the heart’s strength of contraction or contractility. The beta-2 receptors are located in the bronchioles of the lungs and the arteries of the skeletal muscles.

Where are alpha 2 receptors located in the body?

Alpha 2 receptors are found both in the brain and in the periphery. In the brain stem, they modulate sympathetic outflow. Their function in the periphery is not yet fully understood, but they may contribute both to control of sympathetic tone and to local and regional blood flow.

How does precedex work for sedation?

Dexmedetomidine has a unique sleep-like quality of sedation and has the benefit of minimal respiratory depression when used alone. Dexmedetomidine works at α2-receptors both peripherally and centrally; however, the sedative and anxiolytic effects of the drug are mediated through stimulation of central α2-receptors.

What is the most Cardioselective beta-blocker?

Bisoprolol or metoprolol succinate are usually prescribed as they are the most cardioselective beta-blockers, but there is evidence of benefit for a number of other beta-blockers and international guidelines do not specify which beta-blocker to prescribe.

What drugs should not be taken with metoprolol?

Mental health medications: bupropion, fluoxetine, paroxetine, clonidine, thioridazine. Other medications: antiretroviral drugs like ritonavir, antihistamine drugs like diphenhydramine (brand name Benadryl), antimalarial drugs like quinidine, antifungal drugs like terbinafine (brand name Lamisil)